Community Pharmacist

Community pharmacists are the health professionals most accessible to the public. They supply medicines in accordance with a prescription or sell them without prescription when they are legally permitted and also counseling the patients when dispensing the drugs.

Community Pharmacist

Community pharmacists are the health professionals most accessible to the public. They supply medicines in accordance with a prescription or sell them without prescription when they are legally permitted and also counseling the patients when dispensing the drugs.

Prosperous Pharmacist Our Goal

Healthy and Prosperous Pharmacist Community the Goal of Pharmacyportal.blogspot.com

Health Our Primery Concern

Pharmacist your own Health Guide

Pharmacist A Nutritionist

A Pharm-D Doctor Your Health Guide.

Saturday 28 October 2017

Bases of Antimicrobial Chemotherapy and Selection of Antibiotics

Chemotherapy is the term originally used to describe the use of drugs that are selectively toxic to invading microorganisms while having minimal effects on the host.
In conventional manner the definition of chemotherapy which is done by Ehrlich himself who was the inventor of drug against syphilis according to him ** the use of synthetic chemical which destroy the invading infective agents. But now a day antibiotics also included in chemotherapy. ** Antibiotics** are those substance produced by microorganisms  and that stop the growth or kill other microorganisms. But chemotherapy definition is broaden further and cancer cells killing or inhibiting substances are also included in this category.
Note *now a days antibiotics also included those substance which are semi-synthetic just like flouro-quinolones i.e (ciprofloxacin)
Antimicrobial Chemotherapy


Principles of antimicrobial therapy

The difference between the host cell and the invading entity is of immense importance. These differences give the specificity to the drug to be only toxic for the invading pathogens and not to be toxic toward host cells.

Selection of antimicrobial agents
Selection of proper antibiotic depend upon certain factor before the therapy is initiated. The factors are 1) identity of pathogen 2) organism susceptibility to a particular agent 3 ) site of infection 4) patient factor 5 ) safety of the agent and 6) cost.
1)    Identity of the pathogen )__ through several ways the pathogen is identified. Gram staining give a through knowledge about the organism. If the identification process take some time and the infection is sever so treatment should be started before the laboratory reports with an ideal agent this strategy is called empirical therapy. Empirical treatment should be started on the bases of patient’s history. Broad spectrum therapy is initiated initially. In some special situation specific agent are preferred to be used for example gram positive cocci in the spinal fluid of a newborn infant is unlikely to be streptococcus pneumoniae and most likely to be streptococcus agalactiae which is sensitive to penicillin G. Contrast to this gram positive cocci in the spinal fluid of a 40 year old patient is most likely to be S.pneumoniae. This is frequently resistant to penicillin G and often requires treatment with high dose third generation cephalosporin (ceftriaxone) or vancomycin.


2)    Determining antimicrobial susceptibility of infective organism)__  certain drugs are preferred over others in case of certain specific infections. Certain laboratory procedures are followed to identify the susceptibility. These procedures give knowledge about a specific agent which is most active. These procedure give knowledge of selection of bactericidal and bacteriostatic agents also tell us about Minimum inhibitory concentration (MIC) and minimum bactericidal concentration. 

1)    Site of infection)--- site of infection plays an immense role in the finding a specific agent.  Site of just like CNS which is protected by blood brain barrier which impeded the flow of certain drugs. Site of infection depend upon the following factors like size of the drug molecule just like vancomycin cant cross the blood brain barrier and in the same way lipid solubility of a drug may affect it just like lipophilic metronidazole and chloramphenicol can easily cross the blood brain barrier at the other side penicillin G.

The other three Factors like patient factors, safety of the agent when some co-morbidities are there and Cost factors are decided as accordingly to rational drug therapies.  

Friday 27 October 2017

Rang and Dale,S Pharmacology Book PDF Free Download 8th Edition

Rang and Dale,S Pharmacology Book PDF Free Download 8th Edition
A complete A Perfect book for Clinical Pharmacology and Therapeutics
Parasympathetic and Para-Sympathetic System is disused in a Beautiful Manner.
Other Major Topic Like Antidepressants are  also explained here a perfect manner. Do Check It. Need of Every Medical Student (Pharm-D, MBBS, MD, BDS, DPT).

For Downloading Click on the File Below PDF view below. Click on the Arrow at the right Upper Corner of PDF file and then click on the download option after full view. 

Wednesday 25 October 2017

Clinical Pharmacology and Therapeutics Book PDF Free Download

Book of Clinical Pharmacology and Therapeutic covers stuff related to clinical Setups. A good review on Adverse Drug reactions and Patient Profiling. Do Check it.
For Downloading Plz Click on the Arrow on the right side of PDF file and Then after full view click on the the download option. Do Leave your comments about our website. 

Tuesday 24 October 2017

Anesl Book of Pharmaceutics Nineth Edition PDF free Download

Ansel Book Latest Edition
Need of Every Student from 1st Semester to 10 Semester
For Downloading Click on the Arrow on the Right Upper corner of the file below and Click on Download Icon There. 

Hand Book of Instrumentation Free Download

A Nice and Complete Book on Instrumentation.

For Downloading Click On The arrow in the Corner above the file and Click Download Mark there. 

Monday 23 October 2017

Quality Control of Sustained Release Products Full Chapter 4

In this Chapter Quality Control of Sustained Released Products is Explained. 


Quality Control of Syrups and Elixirs Chapter 3 Full Chapter

Syrup Definition: Concentrated aqueous preparations of sugar or sugar substitutes with or without adding flavoring & medicinal agents.

Types of Syrups 
Syrups are classified into 2 main classes:
1.Medicated syrups: contain the medicinal substances.
used for their therapeutic activities.
2.Non-medicated syrups: contain flavouring agents but not the medicinal substances.
used mainly as a vehicle for the medicaments. 
For Further Details Check the slides. Click the full scree icon for full screen  

Sunday 22 October 2017

Quality Control of Solid Dosage form Chapter 2 Quality Management

This Slide Show Contain A complete chapter of Quality Management for 7th semester (4th Professional Pharmacy) Course. 


Check the Slides Below for full view click on the full view icon. 

Scope of Pharmaceutical Quality Management 1st Chapter Q.C

The term quality control refers to procedure or test or technique by which decision may be made regarding whether production is proceeding according to plan and meeting standards established previously.

Quality control is essential:
in the drug development program to ensure that the drug substance and other raw materials are suitable for use in drug product and

to ensure that the drug product manufactured meets the highest quality standards.
Check the Slides For Detailed Info


Saturday 21 October 2017

Introduction to Clinical Pharmacy 1st Chapter PDF Download

Clinical Pharmacy is comparatively recent and variably implemented form of practice, which deals with the patient that how to treat the patient. It select the effective drugs for a patient in short it make reliable the therapy.  Clinical pharmacy include all the services performed by pharmacist practicing in hospital, community pharmacy, nursing homes, home based care services, clinics and other places where medicines are prescribed and used.
The main focus is to change the orientation of pharmacist from product orientation toward the patient orientation. Overall it works on the safe , effective and economic used of medicines for individual patient. They way clinical pharmacy works is on the based philosophy of Pharmaceutical care.

Definition; Clinical pharmacy comprises a set of functions that promote the safe effective and economic use of medicines. It apply specific knowledge of pharmacology, pharmacokinetics, biopharmaceutics and pharmaceutics and therapeutics to the patient care.  
For More Info Check the File Below . A complete Chapter on Clinical Pharmacy Introduction
For Downloading Click on the arrow above the file and Click download option there. 

Friday 20 October 2017

Role of Pharmacist In Emergency/Emergency Pharmacist Role

History:  First emergency was started in US in 1950.  Since then the rate of mortality is highly decreased. The role of pharmacist in emergency department was first time defined in 1970. Initially the role of pharmacist was confined to the drugs distribution in this department. Later on the role was expended to other activities. The primary role of pharmacist in emergency department is divided into two main roles:

a)     Essential Role:  essential role of pharmacist include direct involvement in pharmacotherapy management. Essential role include things like Direct patient care rounds, drug prescription review etc. Parts of essential role include things like :

1)     Direct patient care Rounds:
     IN this case pharmacist is involved in optimization of therapy via controlling errors in drug selections and prescribing. A whole team of health care is involved in this scenario including nurses and physicians. A complete review or selected review of drugs use is done in emergency depending upon the number of pharmacist available. For example when limited number of pharmacist are available then triage system may be followed instead of focusing on all critically ill, high risk patients or selected drug with high chance of interaction are selected to be checked.  This triage system just like first priority” critically ill patient only” then “high risk patient” and/or “selected drug with high chance of drug interactions” is preferred when the number of pharmacists are not according to the need.  

          Medication order review:
 A prospective review of medication order must be done by the pharmacist before the drug is administered to the patient. In some case the review if not done is not compulsory. Just like
1) In- Case of emergency
- when the patient is critical and review time may fall his life in danger so it is good not to have a review. Although selection is done along with the physician.
   2)  If the Delay  of the review harms the patient.
  3) If medical practitioner is itself present there.
When serving in emergency the services provided by the pharmacist depends on the number of patient and number of pharmacist available. When low number of pharmacist are hired in Emergency department the pharmacist work is overloaded. So in this case the medication orders coming for review, the pharmacist will review the orders according to the need.
Majority of emergency orders are one time orders so it is necessary that pharmacist review the order before administration.  Similarly to direct patient care rounds a triage system is also followed here. When running short of time other department pharmacist may be involved through computerized provider order entry (CPOE) system where all of the pharmacist are linked through computerized system with emergency department. Alarm system may be developed where Emergency pharmacist require the help of other pharmacist and is done quickly.

       Medication Therapy Management: 
    Medication therapy management is necessary in Medication use process, whether the therapy selected was safe and effective, sub-optimal, or failed and whether changes to the therapy regimen is needed.  Medication therapy management prevent the insecure use of medicines in future and promote regular use of medicines. 

        Patient care involving high risk medications and procedures:
High risk medications include medicines with narrow therapeutic Index (NTIs). Such drugs must  be used under the strict supervision of pharmacist. similarly alternate procedure used in life saving process must be observed by pharmacist form the bed side of the patient.  Emergency pharmacist should evaluate current procedure associated with the use of high risk medications.  Participation of pharmacist in such process include proper selection, proper doses, preparation of medications and monitoring of therapy.  Several recommendations for reducing errors associated with high risk medications and procedure must be followed i.e smart infusion technology and double medication check system for high risk medications.

         Resuscitation: 
    The role of pharmacist in stabilizing (resuscitation) the patient is crucial. As previously said pharmacist prevent medication error thus prevent any harm to the patient.  Other things pharmacist must do is  immediate medication preparation, providing as instant source of knowledge, making recommendations for alternate route of administration, answering questions regarding drug in emergency room, assessing physicians with differential diagnose related to medication cause  and resuscitation documentation.

     Toxicological emergencies 
     The role of pharmacist can,t be neglected here. As the pharmacist provides as a primary source of drug information.  No toxicological emergency can be done in a better manner without the involvement of pharmacist. In toxicological management Emergency pharmacist should have a proper and through knowledge of antidotes and their administration, supportive therapies, antidote preparation, monitoring antidote effectiveness and safety. 
In order to become a successful and complete member of toxicological team pharmacist must have knowledge and skill or must have gone through some post-graduation courses and exams in this vary field.

          Medication procurement and Preparation: 
      Medication procurement in emergency department presents challenges as compare to the central pharmacy department. Because of the urgent treatment drugs must be readily available.  Medication procurement process in emergency department depends on the number of pharmacist , average number of patient entertained and number of patients available. In case of low profile pharmacy services provided by hospital emergency, drugs may be kept in pavilion, emergency kits which keep all required drug for emergency and similarly automated emergency cabinets.  A satellite pharmacy with compounding ability is best source of medications availability to emergency department. As a separate sterile room may not be possible in emergency departments so a laminar flow hood may be a least choice for IV preparations. If satellite pharmacy is not available the central pharmacy with rapid preparations processes must set up to provide the needs. And Emergency pharmacist itself should be competent in performing such processes.

            Medication Information: 
      Cause of nearly all the medication interactions and errors is lack of information. As an expert of pharmacology and toxicology pharmacist must assure to deliver the regarding information to the health care personals involved in emergency department. Information provided by the pharmacist include information about the rationale use of drug, proper dosing, route of administration, way of administration etc.  Pharmacist should be able to concern primary, secondary and tertiary sources literature when provision of information is need to be delivered to health care personals.

            Documentation: 

    Documentation provide future record about the patient condition and therapy used in emergency. It may be a legal process required in some states. Documentation may be done in various manners and through various ways depending on the institution. It may include electronic devices, internet in a hospital linking various departments or done manually. Manual documentation is done on a paper and is a tedious process and loss of record is a prominent chance. Electronic documentation provided a batter way of documentation and retrieval  of record can be done easily.
b)    Desirable Roles: - Desirable role of pharmacist include those role which are optional which depends upon the skills of pharmacist, time and workload. if desirable roles can be delivered it adds prestige to the standing of pharmacist.
Desirable roles of pharmacist include

      Education:
     The role of EMPs in education can be variable and broad, and it has been mentioned in conjunction with other responsibilities throughout these guidelines. It is desirable for EMPs to participate in the education of other health care providers, including pharmacists and pharmacy staff, pharmacy students, pharmacy residents, physicians, medical residents, mid-level practitioners, nurses, and emergency medical support personnel. The types and levels of education will vary with patient care and administrative workload.

         Research and Scholarly Activities: 
    Three type of researches are conducted by emergency pharmacist. These include “trauma and injury control research” pre-hospital Emergency research and research attributed to other fields but affect emergency. 

Wednesday 18 October 2017

Rational Use of Drugs the need of modern society

Rationale use of Drugs Usually Include 5 Rights. Which include Right patient, Right drugs, Right dose ,Right route  and Right frequency. But these 5 Rights dose not defines the Rational use of drugs. There is a lot more to be added along with these 5 Rights, Just like cost effectiveness, safety concerns, and drug information delivering to the patient.
Rationale Use of Drugs the emerging need of the modern world. According to WHO 50% of Medicines are used irrationally.  Infections are getting stronger and stronger killing more and more people due to antibiotics one of outcome of irrational use of drugs. This antibiotic resistance problem is now a day the most focused focal point in irrational use of drug, but implementation is to be done yet.This topic is dedicated particularly to last semester Pharm-D students. Stay Blessed

Check the Video Below although his way of speaking is not must astonishing but I like the content. Hope you will get some thing out of it 

Hope it was helpful 

Monday 16 October 2017

Physical Examination/Assessment of Human Body and Assessment Methods


Physical Examination is the process by which a medical professional investigates the body of a patient for signs of disease. It generally follows the taking of the medical history—an account of the symptoms as experienced by the patient. Together with the medical history, the physical examination aids in determining the correct diagnosis and devising the treatment plan. Basic skills which are used for physical examination are:   
Inspection, Palpation, percussion, auscultation, which of this method come first depends of the case and area of the body to be examined. Just like when examining the abdominal area, it is best to perform auscultation before percussion or palpation. This will preserve certain auscultatory sounds that should not be elicited or masked by touch. 
Physical-Examination

Inspection:  During this portion of the examination, the physician inspects or looks at different parts of the patient's body. It is visual examination. It requires the use of naked eye. During Physical health care practitioner looks for:
Body features and symmetry appearance, Nutritional state or weight, Skin colour, Frequency and volume of breaths during respiration, Movement of the abdomen and each side of the chest during respiration, Hair distribution, Wounds, Discoloration, Swelling, Tremor etc. However physical examination is not limited to the visualization other organoleptic evaluation like odour and smell , listening of sound etc also included in inspection.     
Palpation:  is a technique used in physical examination in which the examiner feels the texture, size, consistency, and location of certain body parts with the hands. It should not be confused with palpitation which is awareness of heat beats. 
Prior to palpating a patient, some basic principles need to be observed. You should have short fingernails to avoid hurting the patient as well as yourself. Also, you should warm your hands prior to placing them on the patient; cold hands can make a patient’s muscles tense, which can distort assessment findings. Encourage the patient to continue to breathe normally throughout the palpation. Most significantly, inform the patient where, when, and how the touch, will occur, especially when the patient cannot see what you are doing. Palpation may be superficial or deep. Light palpation reveals information on skin texture and moisture; overt, large, or superficial masses; and fluid, muscle guarding, and superficial tenderness. Deep palpation can reveal information about the position of organs and masses, as well as their size, shape, mobility, consistency, and areas of discomfort.
Percussion:  is the technique of striking one object against another to cause vibrations that produce sound. The density of underlying structures produces characteristic sounds. These sounds are diagnostic of normal and abnormal findings. The presence of air, fluid, and solids can be confirmed, as can organ size, shape, and position. Any part of the body can be percussed, but only limited information can be obtained in specific areas such as the heart. The thorax and abdomen are the most frequently percussed locations.
 It is done with the middle finger of one hand tapping on the middle finger of the other hand using a wrist action, which is placed firmly on the body over tissue, not bone. When percussing bony areas such as clavicle the stationary finger can be omitted and the bone is tapped directly. The process of percussion can produce five distinct sounds in the body: flatness, dullness, resonance, hyper-resonance, and tympani. Specific parts of the body elicit distinct percuss-able sounds.

Auscultation:  Auscultation is the act of active listening to body organs to gather information on a patient’s clinical status. Auscultation includes listening to sounds that are voluntarily and involuntarily produced by the body. A deep inspiration a patient takes with the lung assessment illustrates a voluntary sound, and heart sounds illustrate involuntary sounds. A quiet environment is necessary for auscultation. Auscultated sounds should be analyzed in relation to their relative intensity, pitch, duration, quality, and location. Auscultation is done for heart sounds breath sounds and bowl sounds. There are two types of auscultation: direct and indirect.  Direct auscultation involves listening with ear without any amplifier while indirect use stethoscope.

Saturday 14 October 2017

How to Start a Pharmacy?

(Article is Purely for Pakistan other countries Sri Lankans and Indians may adopt the cost by simple conversion to their cost value)
This Article is taken from Ibex Magazine, May be a A non-Pharmacist touch to It. 


Introduction
Retail Pharmacy is an outlet where pre-packed medicine are sold for end consumers. These stores are open in every part of the city . In addition to medicine, a pharmacy can also provide other necessities as well. In other words, if a pharmacy is properly managed it could also work out as a convenience store.

Investment Requirements
The investment required for this business is around 2 million rupees including the cost for inventory , decor and furniture.

Target Audience
Target Audience for this business are users who wish to purchase medicines and other convenience store products.

Location
The location of the pharmacy should have free parking space and should be situated close to the residential. If it is located near a hospital, the flow of customers will also increase.

Profit Margins
The profit margin on retail pharmacy medicines ranges from 15% to 20%.

Business Model
The business model works on simple supply chain model. The retailer buys the products from the company designated distributor and sells the product to the end consumer by keeping the assigned profits and margins. This business model falls under the ministry of health. They have issued different sets of rules which are to be followed by the owner of the pharmacy.

Investment requirement (with breakdown)
• Land – 35,000-40,000/Per Month
• Land Advance- 300000/ One Time
• License fee – 10,000/Annual
• Equipment’s and Interior – 5 Lac (One Time)
• Stock/Inventory – 10 Lac (One Time)
• Qualified Person (If the person planning to open does not hold a pharmacy degree)- 60000/Annual
• Front Enter Staff – 30000/ Per Month (3 Person)

Initial Requirements (registration/equipment)
• Before you start your pharmacy you have to register it with the drug court and obtain proper license from the government. Before opening, an approval from the respective area drug Inspector is required.
• The basic equipment required in a pharmacy is;
– Air conditioner for proper temperature
– Refrigerator for vaccinations

Running Cost
The overall Running cost to open up a pharmacy ranges from 20 Lac to 25 Lac depending upon the scale of the pharmacy and location.

Workforce
• Trained working Front Desk Staff (2 to 3 Persons)
• Cashier (1 Person)
• Sweeper (1 Person)

Marketing
The Marketing tools that could be used for this type of the business are as follows:
• Boucher
• Flyers
• Banners

Breakeven Time
The break even can be achieved within a period of 6 to 12 months depending upon the business size.

Major problems
The major problems are as follows :
• Government Restrictions and Drug Law
• Frequent visits by Drug Inspector
• Mindset of the end consumers
• Credit limit requirement by the customers

Backbone of Business
The Back bone of the business is how you manage your inventory, how much you increase your stock level (shelf level) with the passage of time and how much you incorporate the consumer demands in terms of items in your stock. The business is also dependent on the increasing range of new medicines with new formulation. Keeping the updated variety of medicine also plays a key role.

Copyright Protection  
Notice: This article is for education purpose so copyright protection law is not violated. Entire article is the copy of original source linked below.


Source Of Information Take form Ibex Business  Magazine.  http://www.ibexmag.com/business-plan/open-pharmacy/

Friday 13 October 2017

H2 Receptor Blocker Drugs

The Most Decent Acid Reducing Drugs 

Reasons Why I am Using the title decent for H2 receptors blockers over the other acid reducing drugs Like PPIs and Acid Neutralizing agent (like NaoH) are pretty obvious in the article go through full article and You will find the reason.
Agents Included In H2 Receptors Blockers
Cimetidine (Banned due to Aplastic anemia association) , Famotidine, Ranitidine, and Nizatidine.  

Pharmacokinetics:
All agent except Nizatidine extensively go through first pass effect and show bio-availability of about 50 %. Nizatidine has little first pass effect.  Goes through both renal and hepatic elimination. Dose Reduction is required in moderate to severs renal insufficiency and same with hepatic patients.

Route of Administration and Dosage
Cimetidine:-Parenteral 200mg/2ml , Oral Liquid 300mg/5ml and Oral tablet dosage form 400-800mg. (But don’t use this banned drug)
Ranitidine: -Parenteral 1-25mg/ml, tablets 75-50-300.
Famotidine: -IV bolus, Tablets 10-20mg, gel-caps and suspension 40mg/5ml.
Nizatidine: - Tablets 75 mg tabs and Capsules 150-300 mg.

Cautions in Parenteral Administration
Main thing to be cared about when administering H2 Receptor blockers is that they should be administered with slow IV bolus rate (plunger of injection should not be pressed at one)  and a slow iv infusion rate. The main reason is rapid IV administration cause sever cardiac event which arise from the action of these drug on Histamine receptor on heart may be fetal for cardiac patients. Although the selectivity of these drug for H2 receptors is almost 100 % but there is negligible selectivity for others receptors too which cause this problem.    

Pharmacodynamics
The H 2  antagonists exhibit competitive inhibition at the parietal cell H 2  receptor and suppress basal and meal-stimulated acid secretion in a linear, dose-dependent manner. They are highly selective and do not affect H1  or H3  receptors. The volume of gastric secretion and the concentration of pepsin are also reduced. On two ways H2 receptor blockers reduce acid secretion first through blocking H2 receptors and secondly by diminishing the effect of gastrin on gastrin receptors in the presence of H2 receptor Blockers.
Special Pharmacodynamics information is they reduces nocturnal (Night) acid secretion (which is mainly due to histamine) well compare to meal stimulated acid secretion. Because Meal stimulated acid secretions is dependent on acetyl-choline, gastrin as well as histamine.

(The Most Decent Drugs)
The title decent which I have given to this class of drug compare particularly to PPIs is that they are safe for prolong use without any potential risk of Hyperplasia of Parietal cells. As PPIs block proton pumps on parietal cells they low acid secretion but at the same time gastrin is releasing and developing higher and higher in concentration, leading to potential cause for Hyperplasia of parietal cells which may lead to carcinoma. Other reason which are concerned is that PPIs prolong use leads to weak bones which may be a bad experience for geriatric patient as PPIs drastic use is among the older age. And due to the above reasons they are given after for use of PPIs in chronic conditions.

Clinical Uses of H2 Receptor Blockers
1)Peptic Ulcer 2) Non-Ulcer Dyspepsia 3) Gastroesophageal Reflux Disease (GERD) 4) Stress Related Ulcer  

Adverse Drug Reactions

Except cimetidine (which is banned drug now) others H2 receptor blockers are mostly well tolerated have no side effect except for 3% patients.  Cimetidine has the notorious side effects gynecomastia , impotence and galactorrhea which is due to tendency of Cimetidine inhibits binding of dihydro-testosterone to androgen receptors, inhibits metabolism of estradiol, and increases serum prolactin levels.  The ADR due to which Cimetidine is banned is its tendency of causing aplastic anemia.

Wednesday 11 October 2017

Kohat University Pharmacy Merit List 2017

Click on Merit list to find the merit list

Tuesday 10 October 2017

Drug Interactions

      Definition: Drug Interaction refers to the modification of response of one drug by another when they are administered simultaneously.  
Drug Interactions

OR : Modification of drug response by other substance (food, drug, herbal product) which is simultaneously taken or administered to the patient.
Modification of response is usually quantitive  i.e increases or decreases but sometime it is so that it appears qualitative as abnormal different type of response.
Mechanism of Drug Interaction: Three Kind of Mechanisms is Involved Here:
1)    Pharmaceutical
2)    Pharmacodynamics
3)    Pharmacokinetics
Pharmaceutical Interaction: appear when two drug are chemically and physically unstable with each other and mixed together. They cause sort of interaction chemically (Chemical Reaction i.e neutralization, Hydrolysis etc) or physically (Precipitation, crystallization etc).  
Pharmacodynamics Interaction: Occur when the drug influence the response of each other at receptor level. The two drugs may or may not act on the on the same receptor to produce such effects. Theoretically drugs acting on the same receptors are usually additive. Drugs acting on different receptors may be agonistic, antagonistic or synergistic etc. Pharmacodynamic interactions may be additive, synergistic or antagonistic effect. 
Pharmacokinetic Interactions : may occur when one drug affect the pharmacokinetic processes of the other. Pharmacokinetic processes involves absorption, distribution and elimination (excretion + metabolism).  Sometime drug interactions may be due to one mechanism or combination of these.
Drug Interaction Effects:
They effect of drug interaction may be Additive effect (increase in response), Antagonistic effect (decrease in response) and No effect.
Increase in Effect: this may also be called additive effect.  Additive effect may be useful or harmful.
·       Beneficial Additive Effects : Beneficial additive effects are usually used for the purpose of therapeutic purposes. Just like different anti-hypertensives are give to reduce blood pressure effectively. Same is the case of antibiotic combination and Antidiabetic drug. These combination give batter therapeutic response as compare to single drug administration.

·       Harmful Additive effects: In this case the additive effect dose not goes in favor of patient and give harms to the body. Just like Benzodiazepines and Anti-Histamine may lead to prolongation of sedative and hypnotic effect or may case other effect just like respiratory depression etc. or combination of beta blockers and calcium channel blockers (verapamil) may lead to heart block due to additive effect on Nodal blockage.

Antagonistic effect (Lessened Effect): in this type of interaction the effect of one drug is decreased or antagonized by the presence of other drug. Same as Agonistic effects the antagonistic effects may be beneficial or harmful.
·       Beneficial Antagonistic: Some time antagonism is used for beneficial purposes. Just like in case of the toxicities the effect is antagonized by administering anti-dotes which usually work antagonistically to the original drug. For Example in case of Benzodiazepine toxicity flumazenil is used. Flumazenil works antagonistically to the Benzodiazepine.

·       Harmful Antagonistic effects: Harmful antagonistic effects are usually not accepted. In this case one drug decreases or completely block the required therapeutic effect of the other drugs. Just like in case of NSAIDS (Indomethacin and ibuprofen) Reduces the effect on antihypertensive.



No-Effect: No effect is said when the effect of the drug interaction is very minor or no significant change. 

Sunday 8 October 2017

Anthelmintic Drugs Complete Information

               Microtubules synthesis Inhibitors

Class name Benzimidazole  
Agents included are Thiabendazole,  Albendazole and Mebendazole 
Pharmacy Portal

Pharmacodynamics:- Benzimidazoles act against worms by inhibiting micro-tubules synthesis. They inhibit beta-tubulin factors which further activate a gene. By interacting with a gene it inhibit gene production (prevent protein synthesis) and thus compromise cytoskeletal formation, and due to compromise cytoskeletal formation the locomotion , attachment and other activities of worm stops and lead to death.  

Pharmacokinetics:-  All the drug included in this class are in oral dosage form (tablets and suspensions). They have comparatively different pharmacokinetic profile. Pharmacokinetic profile of each drug is show below.

Albendazole: - Albendazole is a pro-drug and via first-Pass effect in liver it is converted to active form Albendazole-Sulfoxide. Active form of the drug is highly protein bounded and has a high distribution value.

Mebendazole:- Mebendazole is less then 10 % orally absorbed. Just like Albendazole it is highly protein bounded. Same excretion occur through Kidney.  Both Albendazole and Mebendazole has increase in absorption when given with food.

Thiabendazole:-  It may be absorbed through the skin but this rout is not recommended for administration. The drug is rapidly absorbed from GIT and its metabolism is in liver by Glucronidation and sulfonate conjugation and excreted in urine.
ADRs: -  Albendazole is gentle and have fewer side effect then others and it is well tolerated.
Common side effect of these drug are abdominal distress (NVD) , headache , dizziness , liver enzymes elevation, fatigue and some serological problems.
Hypersensitivity may occur (cross Hypersensitivity may occur).  Thiabendazole can cause Stevens-Johnson syndrome and Irreversible liver failure.

Contraindications:-  All Benzimidazoles are contraindicated in pregnancy, children less then 2 year old and liver cirrhosis. 
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Community Pharmacist : And Role of Community Pharmacist

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