Saturday, 28 October 2017
Bases of Antimicrobial Chemotherapy and Selection of Antibiotics
Chemotherapy is the term originally used to describe the use
of drugs that are selectively toxic to invading microorganisms while having
minimal effects on the host.
In conventional manner the definition of chemotherapy which
is done by Ehrlich himself who was the inventor of drug against syphilis
according to him ** the use of synthetic chemical which destroy the invading
infective agents. But now a day antibiotics also included in chemotherapy. **
Antibiotics** are those substance produced by microorganisms and that stop the growth or kill other
microorganisms. But chemotherapy definition is broaden further and cancer cells
killing or inhibiting substances are also included in this category.
Note *now a days antibiotics also included those substance
which are semi-synthetic just like flouro-quinolones i.e (ciprofloxacin)
Principles
of antimicrobial therapy
The difference between the host cell and the invading entity
is of immense importance. These differences give the specificity to the drug to
be only toxic for the invading pathogens and not to be toxic toward host cells.
Selection of
antimicrobial agents
Selection of proper antibiotic depend upon certain factor
before the therapy is initiated. The factors are 1) identity of pathogen 2)
organism susceptibility to a particular agent 3 ) site of infection 4) patient
factor 5 ) safety of the agent and 6) cost.
1)
Identity of the pathogen )__ through several ways the pathogen is
identified. Gram staining give a through knowledge about the organism. If the
identification process take some time and the infection is sever so treatment
should be started before the laboratory reports with an ideal agent this
strategy is called empirical therapy. Empirical treatment should be started on
the bases of patient’s history. Broad spectrum therapy is initiated initially.
In some special situation specific agent are preferred to be used for example
gram positive cocci in the spinal fluid of a newborn infant is unlikely to be
streptococcus pneumoniae and most likely to be streptococcus agalactiae which is
sensitive to penicillin G. Contrast to this gram positive cocci in the spinal
fluid of a 40 year old patient is most likely to be S.pneumoniae. This is
frequently resistant to penicillin G and often requires treatment with high
dose third generation cephalosporin (ceftriaxone) or vancomycin.
2)
Determining antimicrobial
susceptibility of infective organism)__ certain drugs are
preferred over others in case of certain specific infections. Certain
laboratory procedures are followed to identify the susceptibility. These
procedures give knowledge about a specific agent which is most active. These
procedure give knowledge of selection of bactericidal and bacteriostatic agents
also tell us about Minimum inhibitory concentration (MIC) and minimum
bactericidal concentration.
1)
Site of infection)--- site of infection plays an immense
role in the finding a specific agent.
Site of just like CNS which is protected by blood brain barrier which
impeded the flow of certain drugs. Site of infection depend upon the following
factors like size of the drug molecule just like vancomycin cant cross the
blood brain barrier and in the same way lipid solubility of a drug may affect
it just like lipophilic metronidazole and chloramphenicol can easily cross the
blood brain barrier at the other side penicillin G.
The other three Factors like patient
factors, safety of the agent when some co-morbidities are there and Cost
factors are decided as accordingly to rational drug therapies.
Friday, 27 October 2017
Rang and Dale,S Pharmacology Book PDF Free Download 8th Edition
Rang and Dale,S Pharmacology Book PDF Free Download 8th Edition
A complete A Perfect book for Clinical Pharmacology and Therapeutics
Parasympathetic and Para-Sympathetic System is disused in a Beautiful Manner.
Other Major Topic Like Antidepressants are also explained here a perfect manner. Do Check It. Need of Every Medical Student (Pharm-D, MBBS, MD, BDS, DPT).
A complete A Perfect book for Clinical Pharmacology and Therapeutics
Parasympathetic and Para-Sympathetic System is disused in a Beautiful Manner.
Other Major Topic Like Antidepressants are also explained here a perfect manner. Do Check It. Need of Every Medical Student (Pharm-D, MBBS, MD, BDS, DPT).
For Downloading Click on the File Below PDF view below. Click on the Arrow at the right Upper Corner of PDF file and then click on the download option after full view.
Wednesday, 25 October 2017
Clinical Pharmacology and Therapeutics Book PDF Free Download
Book of Clinical Pharmacology and Therapeutic covers stuff related to clinical Setups. A good review on Adverse Drug reactions and Patient Profiling. Do Check it.
For Downloading Plz Click on the Arrow on the right side of PDF file and Then after full view click on the the download option. Do Leave your comments about our website.
For Downloading Plz Click on the Arrow on the right side of PDF file and Then after full view click on the the download option. Do Leave your comments about our website.
Tuesday, 24 October 2017
Anesl Book of Pharmaceutics Nineth Edition PDF free Download
Ansel Book Latest Edition
Need of Every Student from 1st Semester to 10 Semester
For Downloading Click on the Arrow on the Right Upper corner of the file below and Click on Download Icon There.
Need of Every Student from 1st Semester to 10 Semester
For Downloading Click on the Arrow on the Right Upper corner of the file below and Click on Download Icon There.
Hand Book of Instrumentation Free Download
A Nice and Complete Book on Instrumentation.
For Downloading Click On The arrow in the Corner above the file and Click Download Mark there.
Monday, 23 October 2017
Quality Control of Sustained Release Products Full Chapter 4
In this Chapter Quality Control of Sustained Released Products is Explained.
Quality Control of Syrups and Elixirs Chapter 3 Full Chapter
Syrup Definition: Concentrated aqueous preparations of
sugar or sugar substitutes with or without adding flavoring & medicinal
agents.
Types of Syrups
Syrups are classified into 2 main
classes:
1.Medicated
syrups: contain the medicinal substances.
◦used
for their therapeutic activities.
●
2.Non-medicated
syrups: contain flavouring agents but not the
medicinal substances.
◦used
mainly as a vehicle for the medicaments.
For Further Details Check the slides. Click the full scree icon for full screen
Sunday, 22 October 2017
Scope of Pharmaceutical Quality Management 1st Chapter Q.C
The term quality control refers to procedure
or test or technique
by which decision may be made regarding whether production is proceeding according
to plan
and meeting standards established previously.
Quality control is essential:
in the drug
development program to
ensure that the drug substance and
other raw materials are
suitable for use in drug product and
to ensure that the drug
product manufactured
meets the highest quality standards.
Check the Slides For Detailed Info
Saturday, 21 October 2017
Introduction to Clinical Pharmacy 1st Chapter PDF Download
Clinical Pharmacy is comparatively recent and variably
implemented form of practice, which deals with the patient that how to treat
the patient. It select the effective drugs for a patient in short it make reliable
the therapy. Clinical pharmacy include
all the services performed by pharmacist practicing in hospital, community
pharmacy, nursing homes, home based care services, clinics and other places
where medicines are prescribed and used.
The main focus is to change the orientation of pharmacist
from product orientation toward the patient orientation. Overall it works on
the safe , effective and economic used of medicines for individual patient.
They way clinical pharmacy works is on the based philosophy of Pharmaceutical
care.
For More Info Check the File Below . A complete Chapter on Clinical Pharmacy Introduction
For Downloading Click on the arrow above the file and Click download option there.
Friday, 20 October 2017
Role of Pharmacist In Emergency/Emergency Pharmacist Role
History: First emergency was started in US in
1950. Since then the rate of mortality
is highly decreased. The role of pharmacist in emergency department was first
time defined in 1970. Initially the role of pharmacist was confined to the drugs
distribution in this department. Later on the role was expended to other
activities. The primary role of pharmacist in emergency department is divided
into two main roles:
a) Essential Role: essential role of pharmacist include
direct involvement in pharmacotherapy management. Essential role include things
like Direct patient care rounds, drug prescription review etc. Parts of
essential role include things like :
1) Direct patient care Rounds:
IN this case pharmacist is involved in optimization of therapy via controlling errors in drug selections and prescribing. A whole team of health care is involved in this scenario including nurses and physicians. A complete review or selected review of drugs use is done in emergency depending upon the number of pharmacist available. For example when limited number of pharmacist are available then triage system may be followed instead of focusing on all critically ill, high risk patients or selected drug with high chance of interaction are selected to be checked. This triage system just like first priority” critically ill patient only” then “high risk patient” and/or “selected drug with high chance of drug interactions” is preferred when the number of pharmacists are not according to the need.
IN this case pharmacist is involved in optimization of therapy via controlling errors in drug selections and prescribing. A whole team of health care is involved in this scenario including nurses and physicians. A complete review or selected review of drugs use is done in emergency depending upon the number of pharmacist available. For example when limited number of pharmacist are available then triage system may be followed instead of focusing on all critically ill, high risk patients or selected drug with high chance of interaction are selected to be checked. This triage system just like first priority” critically ill patient only” then “high risk patient” and/or “selected drug with high chance of drug interactions” is preferred when the number of pharmacists are not according to the need.
Medication order review:
A prospective review
of medication order must be done by the pharmacist before the drug is
administered to the patient. In some case the review if not done is not
compulsory. Just like
1) In- Case of emergency
1) In- Case of emergency
- when the patient is critical and
review time may fall his life in danger so it is good not to have a review.
Although selection is done along with the physician.
2) If the Delay of the review harms the patient.
3) If medical practitioner is itself present there.
When serving in emergency the services provided by the
pharmacist depends on the number of patient and number of pharmacist available.
When low number of pharmacist are hired in Emergency department the pharmacist
work is overloaded. So in this case the medication orders coming for review, the
pharmacist will review the orders according to the need.
Majority of emergency orders are one time orders so it is
necessary that pharmacist review the order before administration. Similarly to direct patient care rounds a
triage system is also followed here. When running short of time other
department pharmacist may be involved through computerized provider order entry
(CPOE) system where all of the pharmacist are linked through computerized
system with emergency department. Alarm system may be developed where Emergency
pharmacist require the help of other pharmacist and is done quickly.
Medication Therapy Management:
Medication therapy
management is necessary in Medication use process, whether the therapy selected
was safe and effective, sub-optimal, or failed and whether changes to the
therapy regimen is needed. Medication
therapy management prevent the insecure use of medicines in future and promote
regular use of medicines.
Patient care involving high risk medications and procedures:
High risk medications include medicines with narrow
therapeutic Index (NTIs). Such drugs must
be used under the strict supervision of pharmacist. similarly alternate
procedure used in life saving process must be observed by pharmacist form the
bed side of the patient. Emergency
pharmacist should evaluate current procedure associated with the use of high
risk medications. Participation of
pharmacist in such process include proper selection, proper doses, preparation
of medications and monitoring of therapy.
Several recommendations for reducing errors associated with high risk
medications and procedure must be followed i.e smart infusion technology and
double medication check system for high risk medications.
Resuscitation:
The role of pharmacist in stabilizing (resuscitation) the patient is crucial. As previously said pharmacist prevent medication error thus prevent any harm to the patient. Other things pharmacist must do is immediate medication preparation, providing as instant source of knowledge, making recommendations for alternate route of administration, answering questions regarding drug in emergency room, assessing physicians with differential diagnose related to medication cause and resuscitation documentation.
The role of pharmacist in stabilizing (resuscitation) the patient is crucial. As previously said pharmacist prevent medication error thus prevent any harm to the patient. Other things pharmacist must do is immediate medication preparation, providing as instant source of knowledge, making recommendations for alternate route of administration, answering questions regarding drug in emergency room, assessing physicians with differential diagnose related to medication cause and resuscitation documentation.
Toxicological
emergencies
The role of pharmacist can,t be neglected here. As the pharmacist provides as a primary source of drug information. No toxicological emergency can be done in a better manner without the involvement of pharmacist. In toxicological management Emergency pharmacist should have a proper and through knowledge of antidotes and their administration, supportive therapies, antidote preparation, monitoring antidote effectiveness and safety.
The role of pharmacist can,t be neglected here. As the pharmacist provides as a primary source of drug information. No toxicological emergency can be done in a better manner without the involvement of pharmacist. In toxicological management Emergency pharmacist should have a proper and through knowledge of antidotes and their administration, supportive therapies, antidote preparation, monitoring antidote effectiveness and safety.
In order to become a successful and complete member of toxicological
team pharmacist must have knowledge and skill or must have gone through some
post-graduation courses and exams in this vary field.
Medication procurement and Preparation:
Medication procurement in emergency
department presents challenges as compare to the central pharmacy department.
Because of the urgent treatment drugs must be readily available. Medication procurement process in emergency
department depends on the number of pharmacist , average number of patient
entertained and number of patients available. In case of low profile pharmacy
services provided by hospital emergency, drugs may be kept in pavilion,
emergency kits which keep all required drug for emergency and similarly
automated emergency cabinets. A
satellite pharmacy with compounding ability is best source of medications
availability to emergency department. As a separate sterile room may not be
possible in emergency departments so a laminar flow hood may be a least choice
for IV preparations. If satellite pharmacy is not available the central
pharmacy with rapid preparations processes must set up to provide the needs.
And Emergency pharmacist itself should be competent in performing such
processes.
Medication Information:
Cause of nearly all the medication
interactions and errors is lack of information. As an expert of pharmacology
and toxicology pharmacist must assure to deliver the regarding information to
the health care personals involved in emergency department. Information
provided by the pharmacist include information about the rationale use of drug,
proper dosing, route of administration, way of administration etc. Pharmacist should be able to concern primary,
secondary and tertiary sources literature when provision of information is need
to be delivered to health care personals.
Documentation:
Documentation provide future record about the
patient condition and therapy used in emergency. It may be a legal process
required in some states. Documentation may be done in various manners and
through various ways depending on the institution. It may include electronic
devices, internet in a hospital linking various departments or done manually.
Manual documentation is done on a paper and is a tedious process and loss of
record is a prominent chance. Electronic documentation provided a batter way of
documentation and retrieval of record can
be done easily.
b) Desirable Roles: - Desirable role of pharmacist include those role which are optional which
depends upon the skills of pharmacist, time and workload. if desirable roles
can be delivered it adds prestige to the standing of pharmacist.
Desirable roles of pharmacist include
Education:
The role of EMPs in education can be
variable and broad, and it has been mentioned in conjunction with other
responsibilities throughout these guidelines. It is desirable for EMPs to
participate in the education of other health care providers, including pharmacists
and pharmacy staff, pharmacy students, pharmacy residents, physicians, medical
residents, mid-level practitioners, nurses, and emergency medical support
personnel. The types and levels of education will vary with patient care and
administrative workload.
Research and Scholarly Activities:
Three type of researches are
conducted by emergency pharmacist. These include “trauma and injury control
research” pre-hospital Emergency research and research attributed to other
fields but affect emergency.
Wednesday, 18 October 2017
Rational Use of Drugs the need of modern society
Rationale
use of Drugs Usually Include 5 Rights. Which include Right patient, Right drugs, Right
dose ,Right route and Right frequency. But
these 5 Rights dose not defines the Rational use of drugs. There is a lot more
to be added along with these 5 Rights, Just like cost effectiveness, safety
concerns, and drug information delivering to the patient.
Rationale
Use of Drugs the emerging need of the modern world. According to WHO 50% of
Medicines are used irrationally. Infections
are getting stronger and stronger killing more and more people due to antibiotics
one of outcome of irrational use of drugs. This antibiotic resistance problem
is now a day the most focused focal point in irrational use of drug, but implementation
is to be done yet.This topic is dedicated particularly to last semester Pharm-D students. Stay BlessedCheck the Video Below although his way of speaking is not must astonishing but I like the content. Hope you will get some thing out of it
Hope it was helpful
Monday, 16 October 2017
Physical Examination/Assessment of Human Body and Assessment Methods
Physical
Examination is the process by which a medical professional investigates the
body of a patient for signs of disease. It generally follows the taking of the
medical history—an account of the symptoms as experienced by the patient.
Together with the medical history, the physical examination aids in determining
the correct diagnosis and devising the treatment plan. Basic skills which are
used for physical examination are:
Inspection,
Palpation, percussion, auscultation, which of this method come
first depends of the case and area of the body to be examined. Just like when examining the abdominal area, it is best to
perform auscultation before percussion or palpation. This will preserve certain
auscultatory sounds that should not be elicited or masked by touch.
Inspection: During this portion of
the examination, the physician inspects or looks at different parts of the
patient's body. It is visual examination. It requires the use of naked eye.
During Physical health care practitioner looks for:
Body features and symmetry appearance, Nutritional
state or weight, Skin colour, Frequency and volume of breaths during
respiration, Movement of the abdomen and each side of the chest during
respiration, Hair distribution, Wounds, Discoloration, Swelling, Tremor etc.
However physical examination is not limited to the visualization other
organoleptic evaluation like odour and smell , listening of sound etc also
included in inspection.
Palpation: is
a technique used in physical examination in which the examiner feels the
texture, size, consistency, and location of certain body parts with the hands.
It should not be confused with palpitation which is awareness of heat
beats.
Prior
to palpating a patient, some basic principles need to be observed. You should
have short fingernails to avoid hurting the patient as well as yourself. Also,
you should warm your hands prior to placing them on the patient; cold hands can
make a patient’s muscles tense, which can distort assessment findings.
Encourage the patient to continue to breathe normally throughout the palpation.
Most
significantly, inform the patient where, when, and how the touch, will
occur, especially when the patient cannot see what you are doing. Palpation may
be superficial or deep. Light palpation reveals information on skin texture and
moisture; overt, large, or superficial masses; and fluid, muscle guarding, and
superficial tenderness. Deep palpation can reveal information about
the position of organs and masses, as well as their size, shape, mobility,
consistency, and areas of discomfort.
Percussion: is the technique of
striking one object against another to cause vibrations that produce sound. The
density of underlying structures produces characteristic sounds. These sounds
are diagnostic of normal and abnormal findings. The presence of air, fluid, and
solids can be confirmed, as can organ size, shape, and position. Any part of
the body can be percussed, but only limited information can be obtained in
specific areas such as the heart. The thorax and abdomen are the most
frequently percussed locations.
It is done with the middle finger of
one hand tapping on the middle finger of the other hand using a wrist action,
which is placed firmly on the body over tissue, not bone. When percussing bony
areas such as clavicle the stationary finger can be omitted and the bone is
tapped directly. The process of percussion can produce five
distinct sounds in the body: flatness, dullness, resonance, hyper-resonance,
and tympani. Specific parts of the body elicit distinct percuss-able sounds.
Auscultation: Auscultation
is the act of active listening to body organs to gather information on a
patient’s clinical status. Auscultation includes listening to sounds that are
voluntarily and involuntarily produced by the body. A deep inspiration a
patient takes with the lung assessment illustrates a voluntary sound, and heart
sounds illustrate involuntary sounds. A quiet environment is necessary for
auscultation. Auscultated sounds should be analyzed in relation to their
relative intensity, pitch, duration, quality, and location. Auscultation is
done for heart sounds breath sounds and bowl sounds. There are two types of
auscultation: direct and indirect.
Direct auscultation involves listening with ear without any amplifier
while indirect use stethoscope.
Saturday, 14 October 2017
How to Start a Pharmacy?
(Article is Purely for Pakistan other countries Sri Lankans and Indians may adopt the cost by simple conversion to their cost value)
This Article is taken from Ibex Magazine, May be a A non-Pharmacist touch to It.
This Article is taken from Ibex Magazine, May be a A non-Pharmacist touch to It.
Introduction
Retail Pharmacy is an outlet where
pre-packed medicine are sold for end consumers. These stores are open in every
part of the city . In addition to medicine, a pharmacy can also provide other
necessities as well. In other words, if a pharmacy is properly managed it could
also work out as a convenience store.
Investment Requirements
The investment required for this business is around 2 million rupees including the cost for inventory , decor and furniture.
The investment required for this business is around 2 million rupees including the cost for inventory , decor and furniture.
Target Audience
Target Audience for this business are users who wish to purchase medicines and other convenience store products.
Target Audience for this business are users who wish to purchase medicines and other convenience store products.
Location
The location of the pharmacy should have free parking space and should be situated close to the residential. If it is located near a hospital, the flow of customers will also increase.
The location of the pharmacy should have free parking space and should be situated close to the residential. If it is located near a hospital, the flow of customers will also increase.
Profit Margins
The profit margin on retail pharmacy medicines ranges from 15% to 20%.
The profit margin on retail pharmacy medicines ranges from 15% to 20%.
Business Model
The business model works on simple supply chain model. The retailer buys the products from the company designated distributor and sells the product to the end consumer by keeping the assigned profits and margins. This business model falls under the ministry of health. They have issued different sets of rules which are to be followed by the owner of the pharmacy.
The business model works on simple supply chain model. The retailer buys the products from the company designated distributor and sells the product to the end consumer by keeping the assigned profits and margins. This business model falls under the ministry of health. They have issued different sets of rules which are to be followed by the owner of the pharmacy.
Investment requirement (with
breakdown)
• Land – 35,000-40,000/Per Month
• Land Advance- 300000/ One Time
• License fee – 10,000/Annual
• Equipment’s and Interior – 5 Lac (One Time)
• Stock/Inventory – 10 Lac (One Time)
• Qualified Person (If the person planning to open does not hold a pharmacy degree)- 60000/Annual
• Front Enter Staff – 30000/ Per Month (3 Person)
• Land – 35,000-40,000/Per Month
• Land Advance- 300000/ One Time
• License fee – 10,000/Annual
• Equipment’s and Interior – 5 Lac (One Time)
• Stock/Inventory – 10 Lac (One Time)
• Qualified Person (If the person planning to open does not hold a pharmacy degree)- 60000/Annual
• Front Enter Staff – 30000/ Per Month (3 Person)
Initial Requirements (registration/equipment)
• Before you start your pharmacy you have to register it with the drug court and obtain proper license from the government. Before opening, an approval from the respective area drug Inspector is required.
• The basic equipment required in
a pharmacy is;
– Air conditioner for proper temperature
– Refrigerator for vaccinations
– Air conditioner for proper temperature
– Refrigerator for vaccinations
Running Cost
The overall Running cost to open up a pharmacy ranges from 20 Lac to 25 Lac depending upon the scale of the pharmacy and location.
The overall Running cost to open up a pharmacy ranges from 20 Lac to 25 Lac depending upon the scale of the pharmacy and location.
Workforce
• Trained working Front Desk Staff (2 to 3 Persons)
• Cashier (1 Person)
• Sweeper (1 Person)
• Trained working Front Desk Staff (2 to 3 Persons)
• Cashier (1 Person)
• Sweeper (1 Person)
Marketing
The Marketing tools that could be used for this type of the business are as follows:
• Boucher
• Flyers
• Banners
The Marketing tools that could be used for this type of the business are as follows:
• Boucher
• Flyers
• Banners
Breakeven Time
The break even can be achieved within a period of 6 to 12 months depending upon the business size.
The break even can be achieved within a period of 6 to 12 months depending upon the business size.
Major problems
The major problems are as follows :
• Government Restrictions and Drug Law
• Frequent visits by Drug Inspector
• Mindset of the end consumers
• Credit limit requirement by the customers
The major problems are as follows :
• Government Restrictions and Drug Law
• Frequent visits by Drug Inspector
• Mindset of the end consumers
• Credit limit requirement by the customers
Backbone of Business
The Back bone of the business is how you manage your inventory, how much you increase your stock level (shelf level) with the passage of time and how much you incorporate the consumer demands in terms of items in your stock. The business is also dependent on the increasing range of new medicines with new formulation. Keeping the updated variety of medicine also plays a key role.
The Back bone of the business is how you manage your inventory, how much you increase your stock level (shelf level) with the passage of time and how much you incorporate the consumer demands in terms of items in your stock. The business is also dependent on the increasing range of new medicines with new formulation. Keeping the updated variety of medicine also plays a key role.
Copyright Protection
Notice: This article is for education purpose so copyright
protection law is not violated. Entire article is the copy of original source
linked below.
Source Of Information Take form Ibex Business Magazine.
http://www.ibexmag.com/business-plan/open-pharmacy/
Friday, 13 October 2017
H2 Receptor Blocker Drugs
The Most Decent
Acid Reducing Drugs
Reasons Why I am Using the title decent for H2 receptors
blockers over the other acid reducing drugs Like PPIs and Acid Neutralizing
agent (like NaoH) are pretty obvious in the article go through full article and
You will find the reason.
Agents Included In H2
Receptors Blockers
Cimetidine (Banned due to Aplastic anemia
association) , Famotidine, Ranitidine, and
Nizatidine.
Pharmacokinetics:
All agent except Nizatidine extensively go through first pass
effect and show bio-availability of about 50 %. Nizatidine has little first
pass effect. Goes through both renal and
hepatic elimination. Dose Reduction is required in moderate to severs renal
insufficiency and same with hepatic patients.
Route of Administration and
Dosage
Cimetidine:-Parenteral 200mg/2ml , Oral Liquid
300mg/5ml and Oral tablet dosage form 400-800mg. (But don’t use this banned
drug)
Ranitidine: -Parenteral 1-25mg/ml, tablets
75-50-300.
Famotidine: -IV bolus, Tablets 10-20mg, gel-caps
and suspension 40mg/5ml.
Nizatidine: - Tablets 75 mg tabs and Capsules
150-300 mg.
Cautions in Parenteral
Administration
Main thing to be cared about when administering H2 Receptor
blockers is that they should be administered with slow IV bolus rate (plunger
of injection should not be pressed at one)
and a slow iv infusion rate. The main reason is rapid IV administration
cause sever cardiac event which arise from the action of these drug on Histamine receptor on heart may be fetal for cardiac patients. Although the selectivity
of these drug for H2 receptors is almost 100 % but there is negligible
selectivity for others receptors too which cause this problem.
Pharmacodynamics
The H 2 antagonists
exhibit competitive inhibition at the parietal cell H 2 receptor and suppress basal and
meal-stimulated acid secretion in a linear, dose-dependent manner. They are
highly selective and do not affect H1 or
H3 receptors. The volume of gastric
secretion and the concentration of pepsin are also reduced. On two ways H2
receptor blockers reduce acid secretion first through blocking H2 receptors and
secondly by diminishing the effect of gastrin on gastrin receptors in the
presence of H2 receptor Blockers.
Special
Pharmacodynamics information is they reduces nocturnal (Night) acid secretion (which is mainly
due to histamine) well compare to meal stimulated acid secretion. Because Meal
stimulated acid secretions is dependent on acetyl-choline, gastrin as well as
histamine.
(The Most Decent Drugs)
The title decent which I have given to this class of drug compare
particularly to PPIs is that they are safe for prolong use without any
potential risk of Hyperplasia of Parietal cells. As PPIs block proton pumps on
parietal cells they low acid secretion but at the same time gastrin is
releasing and developing higher and higher in concentration, leading to potential
cause for Hyperplasia of parietal cells which may lead to carcinoma. Other reason which are concerned is
that PPIs prolong use leads to weak bones which may be a bad experience for
geriatric patient as PPIs drastic use is among the older age. And due to the above reasons they are given after for use of PPIs in chronic conditions.
Clinical Uses of H2
Receptor Blockers
1)Peptic Ulcer 2) Non-Ulcer Dyspepsia 3) Gastroesophageal
Reflux Disease (GERD) 4) Stress Related Ulcer
Adverse Drug Reactions
Except cimetidine (which is banned drug now) others H2
receptor blockers are mostly well tolerated have no side effect except for 3%
patients. Cimetidine has the
notorious side effects gynecomastia , impotence and galactorrhea which is due
to tendency of Cimetidine inhibits binding of dihydro-testosterone to androgen
receptors, inhibits metabolism of estradiol, and increases serum prolactin
levels. The ADR due to which Cimetidine
is banned is its tendency of causing aplastic anemia.
Wednesday, 11 October 2017
Tuesday, 10 October 2017
Drug Interactions
Definition: Drug Interaction refers to the
modification of response of one drug by another when they are administered
simultaneously.
OR : Modification of drug response by other substance
(food, drug, herbal product) which is simultaneously taken or administered to
the patient.
Modification of response is usually quantitive i.e increases or decreases but sometime it is
so that it appears qualitative as abnormal different type of response.
Mechanism of Drug Interaction: Three Kind of Mechanisms is Involved
Here:
1)
Pharmaceutical
2)
Pharmacodynamics
3)
Pharmacokinetics
Pharmaceutical Interaction: appear
when two drug are chemically and physically unstable with each other and mixed
together. They cause sort of interaction chemically (Chemical Reaction i.e
neutralization, Hydrolysis etc) or physically (Precipitation, crystallization
etc).
Pharmacodynamics Interaction: Occur when the drug influence the
response of each other at receptor level. The two drugs may or may not act on
the on the same receptor to produce such effects. Theoretically drugs acting on
the same receptors are usually additive. Drugs acting on different receptors
may be agonistic, antagonistic or synergistic etc. Pharmacodynamic interactions
may be additive, synergistic or antagonistic effect.
Pharmacokinetic Interactions : may occur when one drug affect the
pharmacokinetic processes of the other. Pharmacokinetic processes involves
absorption, distribution and elimination (excretion + metabolism). Sometime drug interactions may be due to one
mechanism or combination of these.
Drug Interaction Effects:
They effect of drug interaction may be Additive effect
(increase in response), Antagonistic effect (decrease in response) and No
effect.
Increase in Effect: this may also be called additive
effect. Additive effect may be useful or
harmful.
·
Beneficial Additive Effects : Beneficial additive effects are
usually used for the purpose of therapeutic purposes. Just like different
anti-hypertensives are give to reduce blood pressure effectively. Same is the
case of antibiotic combination and Antidiabetic drug. These combination give
batter therapeutic response as compare to single drug administration.
·
Harmful Additive effects: In this case the
additive effect dose not goes in favor of patient and give harms to the body.
Just like Benzodiazepines and Anti-Histamine may lead to prolongation of
sedative and hypnotic effect or may case other effect just like respiratory
depression etc. or combination of beta blockers and calcium channel blockers
(verapamil) may lead to heart block due to additive effect on Nodal blockage.
Antagonistic effect (Lessened
Effect): in this
type of interaction the effect of one drug is decreased or antagonized by the
presence of other drug. Same as Agonistic effects the antagonistic effects may
be beneficial or
harmful.
·
Beneficial Antagonistic: Some time antagonism is used for beneficial purposes.
Just like in case of the toxicities the effect is antagonized by administering
anti-dotes which usually work antagonistically to the original drug. For
Example in case of Benzodiazepine toxicity flumazenil is used. Flumazenil works
antagonistically to the Benzodiazepine.
·
Harmful Antagonistic effects: Harmful antagonistic effects are
usually not accepted. In this case one drug decreases or completely block the
required therapeutic effect of the other drugs. Just like in case of NSAIDS
(Indomethacin and ibuprofen) Reduces the effect on antihypertensive.
No-Effect: No effect is said when the effect of
the drug interaction is very minor or no significant change.
Sunday, 8 October 2017
Anthelmintic Drugs Complete Information
Microtubules synthesis Inhibitors
Class name Benzimidazole
Pharmacodynamics:- Benzimidazoles act against worms by inhibiting
micro-tubules synthesis. They inhibit beta-tubulin factors which further
activate a gene. By interacting with a gene it inhibit gene production (prevent
protein synthesis) and thus compromise cytoskeletal formation, and due to compromise
cytoskeletal formation the locomotion , attachment and other activities of worm
stops and lead to death.
Pharmacokinetics:- All the drug included in this class are in oral dosage form
(tablets and suspensions). They have comparatively different pharmacokinetic
profile. Pharmacokinetic profile of each drug is show below.
Mebendazole:- Mebendazole
is less then 10 % orally absorbed. Just like Albendazole it is highly protein
bounded. Same excretion occur through Kidney.
Both Albendazole and Mebendazole has increase in absorption when given
with food.
Thiabendazole:- It may be absorbed through the
skin but this rout is not recommended for administration. The drug is rapidly
absorbed from GIT and its metabolism is in liver by Glucronidation and
sulfonate conjugation and excreted in urine.
ADRs: - Albendazole is gentle and have fewer
side effect then others and it is well tolerated.
Common side effect of these drug are
abdominal distress (NVD) , headache , dizziness , liver enzymes elevation,
fatigue and some serological problems.
Hypersensitivity may occur (cross
Hypersensitivity may occur).
Thiabendazole can cause Stevens-Johnson syndrome and Irreversible liver
failure.
Contraindications:- All Benzimidazoles are
contraindicated in pregnancy, children less then 2 year old and liver
cirrhosis.
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